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Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

A |     在无锡梅里古镇的3202022291体彩店，90后业主马双深耕体彩行业多年，针对年轻人群体打造结合古镇文旅氛围与潮流趋势的特色主题门店。门店以潮流休闲 + 赛事氛围为设计核心，融合主题装饰、打卡展区、休闲观赛区，兼顾专业购彩服务与休闲体验，整体风格和梅里古镇风貌相得益彰。

B | 打造过程中，既要遵守古镇统一装修规范，协调外立面与室内布局，又兼顾从传统售彩到氛围运营的转型。    

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。门店形象升级后，经营变化十分明显。

C | 高颜值的环境吸引了大批年轻游客和本地年轻人主动进店，尤其是顶呱刮等即开型彩票备受欢迎。依托门店特色，店内也持续开展各色活动：借助古镇客流推出打卡有礼活动，围绕各类足球赛事举办观赛互动，同时优化服务，用通俗方式讲解玩法，坚守理性购彩理念。未来这家景区体彩网点会继续发挥特色门店优势，结合文旅场景与赛事节点丰富活动形式，用心做好服务，让体彩被更多年轻人喜爱，把小店经营得越来越好。网点编号：3202022291网点地址：无锡市新吴区梅里古镇吴音水岸206-103北侧。

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